About this Medicine article

A New MRI Measure to Early Differentiate Progressive Supranuclear Palsy From De Novo Parkinson's Disease in Clinical Practice: An International Study by Andrea Quattrone; Angelo Antonini; David E. Vaillancourt; Klaus Seppi; Roberto Ceravolo; Antonio P. Strafella; Maurizio Morelli; Salvatore Nigro; Basilio Vescio; Maria G. Bianco; Roberta Vasta; Pier Paolo Arcuri; Luca Weis; Eleonora Fiorenzato; Roberta Biundo; Roxana G. Burciu; Florian Krismer; Nikolaus R. McFarland; Christoph Mueller; Elke R. Gizewski; Mirco Cosottini; Eleonora Del Prete; Sonia Mazzucchi; Aldo Quattrone is a Medicine article available to read on EtoBox.

## Background: Enlargement of the third ventricle has been reported in atypical parkinsonism. we investigated whether the measurement of third ventricle width could distinguish parkinson's disease (pd) from progressive supranuclear palsy (psp). ## Methods: We assessed a new mr t1-weighted measurement (third ventricle width/internal skull diameter) in a training cohort of 268 participants (98 pd, 73 psp, 98 controls from our center) and in a testing cohort of 291 participants (82 de novo pd patients and 133 controls from the parkinson's progression markers initiative, 76 early-stage psp from an international research group). pd diagnosis was confirmed after a 4-year follow-up. diagnostic performance of the third ventricle/internal skull diameter was assessed using receiver operating characteristic curve with bootstrapping; the area under the curve of the training cohort was compared with the area under the curve of the testing cohort using the de long test. ## Results: In both cohorts, third ventricle/internal skull diameter values did not differ between pd and controls but were significantly lower in pd than in psp patients (p < 0.0001). in pd, third ventricle/internal skull diamet

Author

Andrea Quattrone; Angelo Antonini; David E. Vaillancourt; Klaus Seppi; Roberto Ceravolo; Antonio P. Strafella; Maurizio Morelli; Salvatore Nigro; Basilio Vescio; Maria G. Bianco; Roberta Vasta; Pier Paolo Arcuri; Luca Weis; Eleonora Fiorenzato; Roberta Biundo; Roxana G. Burciu; Florian Krismer; Nikolaus R. McFarland; Christoph Mueller; Elke R. Gizewski; Mirco Cosottini; Eleonora Del Prete; Sonia Mazzucchi; Aldo Quattrone

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2020

Language

EN

Field

Medicine (Health Sciences)