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Can I read Clinical Efficacy on Severe Acute Radiation Dermatitis Treated by Topical Compound Danxiong Granules in Patients Receiving Radiation: A Prospective Randomized Trial on EtoBox?
Clinical Efficacy on Severe Acute Radiation Dermatitis Treated by Topical Compound Danxiong Granules in Patients Receiving Radiation: A Prospective Randomized Trial by Y. Zhang; Y. Zhao; J. Yi; P.A. Tian is a Medicine article available to read on EtoBox.
What is Clinical Efficacy on Severe Acute Radiation Dermatitis Treated by Topical Compound Danxiong Granules in Patients Receiving Radiation: A Prospective Randomized Trial about?
Purpose/Objective(s) Radiation dermatitis (RD) is one of the most common acute toxicities induced by radiation therapy (RT). The preliminary study demonstrated the Compound Danxiong Granules (CDG), a traditional Chinese medicine, had promising outcome in RD. To evaluate the efficacy of topical CDG in the treatment of ≥ grade 3 acute radiation dermatitis. Materials/Methods This prospective, randomized, open-label phase 2 clinical trial (ChiCTR1900021339) enrolled patients who had histologically proven malignant tumor, with grade 3 acute RD in the radiation field within 30 days after radiotherapy, in accordance with the CTCAE 4.0 version. We randomly assigned patients (2:1) to receive either CDG treatment (CDG group), or standard of care of recombinant human epidermal growth factor (Gene Time, control group), using a computer-generated randomization list. Application of the CDG via topical washes lasted 20 minutes, twice daily. Grading of RD was performed by independent radiation oncologist every day. The primary endpoint was the recovery time from grade 3 dropped to grade 1. Results 90 patients in our institution were randomized between January 2019 and December 2021. Of 90 patients
Who reads Clinical Efficacy on Severe Acute Radiation Dermatitis Treated by Topical Compound Danxiong Granules in Patients Receiving Radiation: A Prospective Randomized Trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Y. Zhang; Y. Zhao; J. Yi; P.A. Tian
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)