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Induction of a Metastatogenic Tumor Cell Type by Neurotransmitters and Its Pharmacological Inhibition by Established Drugs by Kerstin Lang; Theodore L. Drell IV; Antje Lindecke; Bernd Niggemann; Christian Kaltschmidt; Kurt S. Zaenker; Frank Entschladen is a Medicine article available to read on EtoBox.
What is Induction of a Metastatogenic Tumor Cell Type by Neurotransmitters and Its Pharmacological Inhibition by Established Drugs about?
## Abstract The active migration of tumor cells, a crucial requirement for metastasis development and cancer progression, is regulated by signal substances including neurotransmitters. We investigated the migration of tumor cells within a three‐dimensional collagen matrix using time‐lapse videomicroscopy and computer‐assisted analysis of the migration path. Tumor cell migration is induced by norepinephrine, dopamine and substance P. We show that this induced migration, using MDA‐MB‐468 breast and PC‐3 prostate carcinoma cells, can be inhibited by using specific, clinically established receptor antagonists to the β2‐adrenoceptor, the D2 receptor, or the neurokinin‐1 receptor, respectively. All of the investigated neurotransmitters significantly activated the cyclic adenosine‐monophosphate response element binding protein (CREB). Furthermore, microarray analysis revealed changes of gene expression toward a highly motile tumor cell type, including an upregulation of the α2 integrin, which is an essential adhesion receptor for collagen in migration. The gene for the tumor suppressor gelsolin was downregulated. These 2 critical alterations were confirmed on the protein level by flow‐cyt
Who reads Induction of a Metastatogenic Tumor Cell Type by Neurotransmitters and Its Pharmacological Inhibition by Established Drugs?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kerstin Lang; Theodore L. Drell IV; Antje Lindecke; Bernd Niggemann; Christian Kaltschmidt; Kurt S. Zaenker; Frank Entschladen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)