Can I read Minimum Information and Guidelines for Reporting a Multiplexed Assay of Variant Effect on EtoBox?

Minimum Information and Guidelines for Reporting a Multiplexed Assay of Variant Effect by Melina Claussnitzer; Victoria N. Parikh; Alex H. Wagner; Jeremy A. Arbesfeld; Carol J. Bult; Helen V. Firth; Lara A. Muffley; Alex N. Nguyen Ba; Kevin Riehle; Frederick P. Roth; Daniel Tabet; Benedetta Bolognesi; Andrew M. Glazer; Alan F. Rubin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Minimum Information and Guidelines for Reporting a Multiplexed Assay of Variant Effect about?

Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines have led to a heterogeneous mix of data formats and descriptions, which complicates the downstream use of the resulting datasets. To address these issues and promote reproducibility and reuse of MAVE data, we define a set of minimum information standards for MAVE data and metadata and outline a controlled vocabulary aligned with established biomedical ontologies for describing these experimental designs. ## Supplementary Information The online version contains supplementary material available at 10.1186/s13059-024-03223-9.

Who reads Minimum Information and Guidelines for Reporting a Multiplexed Assay of Variant Effect?

Author

Melina Claussnitzer; Victoria N. Parikh; Alex H. Wagner; Jeremy A. Arbesfeld; Carol J. Bult; Helen V. Firth; Lara A. Muffley; Alex N. Nguyen Ba; Kevin Riehle; Frederick P. Roth; Daniel Tabet; Benedetta Bolognesi; Andrew M. Glazer; Alan F. Rubin

Publisher

Springer Science and Business Media LLC

Published

2024

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)