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A93 No Increase In Immunomodulator Use In Combination With Anti-tnf Therapy In The Post Sonic Era by E Elias; A Oketola; L Targownik; H Singh; C N Bernstein is a Medicine article available to read on EtoBox.

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## Background: The SONIC trial in 2010 definitively proved the superiority of anti tumor necrosis factor (anti-TNF) therapy in combination with thiopurines over anti-TNF monotherapy in persons with moderate to severe CD. Despite high-quality evidence supporting combination therapy, there is a scarcity of data about the impact of this trial on the utilization of combination therapy (anti-TNF plus thiopurines or methotrexate) in clinical practice. Aims: We assessed the prevalence of combination therapy usage by all Manitoba gastroenterologists both pre and post publication of the landmark SONIC trial in 2010. Methods: All 23 prescribers of anti-TNF medications for IBD in Manitoba agreed to participate in the study. Patient charts were reviewed, with demographics, disease characteristics, and prior IBD treatments recorded from time of first contact with a gastroenterologist. The pre-SONIC group was defined as persons who received their first anti TNF treatment between 2005 and 2009, and the post-SONIC group as those who started treatment between 2011 and 2015; subjects starting therapy in 2010 were excluded. The proportion of subjects using combination therapy was compared between the

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Author

E Elias; A Oketola; L Targownik; H Singh; C N Bernstein

Publisher

Oxford University Press; [Oxford]: Oxford University Press; Oxford University Press (OUP) (ISSN 2515-2084)

Published

2018

Language

EN

Field

Medicine (Health Sciences)