Can I read Genetic Phenotypes of Alzheimer’s Disease: Mechanisms and Potential Therapy on EtoBox?

Genetic Phenotypes of Alzheimer’s Disease: Mechanisms and Potential Therapy by Meina Quan; Shuman Cao; Qi Wang; Shiyuan Wang; Jianping Jia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Genetic Phenotypes of Alzheimer’s Disease: Mechanisms and Potential Therapy about?

Years of intensive research has brought us extensive knowledge on the genetic and molecular factors involved in Alzheimer's disease (AD). In addition to the mutations in the three main causative genes of familial AD (FAD) including __presenilins__ and __amyloid precursor protein__ genes, studies have identified several genes as the most plausible genes for the onset and progression of FAD, such as __triggering receptor expressed on myeloid cells 2__, __sortilin-related receptor 1__, and __adenosine triphosphate-binding cassette transporter subfamily A member 7__. The __apolipoprotein E ε4__ allele is reported to be the strongest genetic risk factor for sporadic AD (SAD), and it also plays an important role in FAD. Here, we reviewed recent developments in genetic and molecular studies that contributed to the understanding of the genetic phenotypes of FAD and compared them with SAD. We further reviewed the advancements in AD gene therapy and discussed the future perspectives based on the genetic phenotypes.

Who reads Genetic Phenotypes of Alzheimer’s Disease: Mechanisms and Potential Therapy?

Author

Meina Quan; Shuman Cao; Qi Wang; Shiyuan Wang; Jianping Jia

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)