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Anthropomorphic Tissue-mimicking Phantoms for Oximetry Validation in Multispectral Optical Imaging by Dreher, Kris Kristoffer; Groehl, Janek; Grace, Friso; Ayala, Leonardo A.; Nölke, Jan-Hinrich; Bender, Christoph J; Watt, Melissa J; White, Catherine-Louise; Tao, Ran; Johnen, Wibke; Tizabi, Minu Dietlinde; Seitel, Alexander; Maier-Hein, Lena; Bohndiek, Sarah Elizabeth is a scholarly article available to read on EtoBox.

What is Anthropomorphic Tissue-mimicking Phantoms for Oximetry Validation in Multispectral Optical Imaging about?

Significance: Optical imaging of blood oxygenation (sO$_2$) can be achieved based on the differential absorption spectra of oxy- and deoxy-haemoglobin. A key challenge in realising clinical validation of the sO$_2$ biomarkers is the absence of reliable sO$_2$ reference standards, including test objects. Aim: To enable quantitative testing of multispectral imaging methods for assessment of sO$_2$ by introducing anthropomorphic phantoms with appropriate tissue-mimicking optical properties. Approach: We used the stable copolymer-in-oil base material to create physical anthropomorphic structures and optimised dyes to mimic the optical absorption of blood across a wide spectral range. Using 3D-printed phantom moulds generated from a magnetic resonance image of a human forearm, we moulded the material into an anthropomorphic shape. Using both reflectance hyperspectral imaging (HSI) and photoacoustic tomography (PAT), we acquired images of the forearm phantoms and evaluated the performance of linear spectral unmixing (LSU). Results: Based on 10 fabricated forearm phantoms with vessel-like structures featuring five distinct sO$_2$ levels (between 0 and 100%), we showed that the measured ab

Author

Dreher, Kris Kristoffer; Groehl, Janek; Grace, Friso; Ayala, Leonardo A.; Nölke, Jan-Hinrich; Bender, Christoph J; Watt, Melissa J; White, Catherine-Louise; Tao, Ran; Johnen, Wibke; Tizabi, Minu Dietlinde; Seitel, Alexander; Maier-Hein, Lena; Bohndiek, Sarah Elizabeth

Published

2025

Language

EN