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Signal transduction and white cell maturation via extracellular ATP and the P2Y~11~ receptor by Weyden, Louise Van Der; Conigrave, Arthur D; Morris, Michael B is a Immunology and Microbiology article available to read on EtoBox.

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Extracellular ATP promotes a wide range of physiological effects in many tissues. Of particular interest is the effect of ATP on leukaemia‐derived HL‐60 and NB4 cell lines, which are induced to mature to neutrophil‐like cells. The differentiation process appears to be mediated by ATP binding to a cell‐surface purinergic P2Y receptor, resulting in the stimulation of adenylyl cyclase, elevation of cAMP levels and activation of protein kinase A. In 1997, a novel ATP‐selective P2Y receptor, P2Y~11~, was cloned and shown to be linked to both cAMP and Ca^2+^ signalling pathways. The pharmacological profile of ATP analogues used by P2Y~11~ for cAMP production in transfected cells is reviewed in the present paper and shown to be closely similar to the profiles for cAMP production and differentiation of myeloblastic HL‐60 cells and promyelocytic NB4 cells, both of which express P2Y~11~. Additional data are provided showing that HL‐60 mature to neutrophil‐like cells in response to extracellular ATP, as measured by upregulation of the __N__‐formyl peptide receptor, __N__‐formyl peptide‐mediated actin polymerization and superoxide production. It is proposed that P2Y~11~ is responsible for the

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Author

Weyden, Louise Van Der; Conigrave, Arthur D; Morris, Michael B

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); John Wiley and Sons Inc.; Wiley (ISSN 0818-9641)

Published

2000

Language

EN

Field

Immunology and Microbiology (Life Sciences)