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This study evaluates the effectiveness of three chitosan formulations as adjuvants for a GnRH-I peptide-based vaccine, which typically has poor immunogenicity. The results indicate that chitosan can significantly enhance immune responses, particularly increasing IgG isotype 1 levels, and effectively neutralize GnRH hormone, thereby reducing steroidogenesis and spermatogenesis in male rats. The findings suggest that chitosan formulations could be a viable option for improving peptide vaccine immunogenicity.

Author

joseavendano97

Language

EN