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0 2 Nutrition for Healthy Skin 3 Foreword 5 Preface 6 Contents 7 1 9 Part I: Nutrition and Skin: The Scientific Basis 9 2 10 1: Cutaneous Changes in Nutritional Diseases 10 1.1 Nutritional Deficiencies 10 1.1.1 Marasmus and Kwashiorkor 10 1.1.2 Essential Fatty Acid Deficiency 12 1.1.3 Vitamin Deficiencies 12 1.1.4 Trace Element Deficiencies 15 1.2 Excess Nutrition 17 1.2.1 Obesity 17 1.2.2 Hypervitaminoses 17 1.2.3 Trace Element Deposition 18 1.3 Abnormalities of Amino Acid Metabolism 18 1.4 Nutrition, Skin Physiology, and Skin Pathology 19 References 19 3 21 2: Skin Aging 21 Core Messages 21 2.1 Introduction 21 2.2 Mechanisms of UV-Induced Photoaging 23 2.3 Mitochondrial DNA Mutations and Photoaging 23 2.4 Connective-Tissue Alterations in Photoaging: The Role of Matrix Metalloproteinases and Collagen Synthesis 25 2.5 UV-Induced Modulation of Vascularization 26 2.6 Photoaging as a Chronic Inflammatory Process 27 2.7 Protein Oxidation and Photoaging 27 2.8 Infrared a Radiation-Induced Retrograde Signaling 27 2.9 Concluding Remarks: The Defective Powerhouse Model of Photoaging of Human Skin 28 References 29 4 31 3: Non-melanoma Skin Cancer 31 Core Messages 31 3.1 General Overview 3

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Adobe InDesign CS3 (5.0.4)

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EN