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Enhanced Tumor Targeting and Radiotherapy by Quercetin Loaded Biomimetic Nanoparticles by Huang, Chunyu; Chen, Tongkai; Zhu, Daoming; Huang, Qinqin is a Engineering article available to read on EtoBox.

What is Enhanced Tumor Targeting and Radiotherapy by Quercetin Loaded Biomimetic Nanoparticles about?

In Chinese traditional medicine, quercetin (QT) plays a fundamental role in the treatment of asthma, as an anti-allergen and to lower blood pressure. Recent evidence suggests that QT can improve tumor radiosensitivity through multiple mechanisms. However, poor tumor tissue targeting ability and low water solubility of QT limit its usefulness in the treatment of cancers. Herein, we designed a novel drug delivery system (CQM) consisting of inner QT loaded mesoporous silica nanoparticles (MSNs) and outer cancer cell membranes (CM). The developed nanoplatform had strong anti-cancer effects under X-ray irradiation and good QT loading characteristics. In addition, CQM effectively targeted tumor tissues. Results of __in vitro__ and __in vivo__ experiments demonstrated that the developed CQM drug delivery system has excellent tumor targeting ability and effectively inhibited tumor growth. Therefore, the CQM platform realized targeted drug delivery and radiotherapy sensitization, which provided a newfangled idea of cancer treatment.

Who reads Enhanced Tumor Targeting and Radiotherapy by Quercetin Loaded Biomimetic Nanoparticles?

Author

Huang, Chunyu; Chen, Tongkai; Zhu, Daoming; Huang, Qinqin

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2013- (ISSN 2296-2646)

Published

2020

Language

EN

Field

Engineering (Physical Sciences)