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What is Pro Tacs about?

PROTACs are a class of drugs designed to bring E3 ligases and target proteins into close proximity for ubiquitination, enabling targeted protein degradation. They offer advantages like repeatable degradation and the ability to downregulate targets without compensatory increases in protein expression, but face challenges such as poor cell permeability and the need for known ligands. The document also discusses the design considerations for PROTACs, including linker properties and the use of molecular glues i

Author

Viena Lau

Language

EN