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This study demonstrates that increased protein stability enhances the evolvability of proteins by allowing them to accept a broader range of beneficial mutations while maintaining their native structure. Experiments with cytochrome P450 BM3 variants showed that stabilized proteins produced more unique improved mutants compared to their marginally stable counterparts. The findings establish a crucial link between protein stability and evolution, suggesting implications for natural protein evolution and prote

Author

Rubén Agudo Torres

Language

EN