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Plerixafor injection: a hematopoietic stem cell mobilizer in non-Hodgkin lymphoma and multiple myeloma by Esa Jantunen; Ville Varmavuo; Jaakko Valtola is a Medicine article available to read on EtoBox.

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## Introduction: A combination of granulocyte colony-stimulating factor (g-csf) and chemotherapy or g-csf alone are the most common mobilization regimens for autotransplantations. plerixafor is used for mobilization of cd34(+) cells with g-csf in non-hodgkin lymphoma (nhl) and myeloma (mm) patients. ## Areas covered: The available phase ii and iii data on plerixafor has been reviewed. the efficacy of plerixafor in the mobilization of cd34(+) cells in predicted poor mobilizers as well as in patients who had failed a mobilization has been evaluated. the pre-emptive use of plerixafor as well as studies on cost-effectiveness are covered. also effects in the composition of the collected grafts along with the data on long-term outcome of plerixafor-mobilized patients is discussed. expert commentary: plerixafor combined with g-csf mobilizes cd34(+) cells more efficiently than g-csf alone in patients with nhl or mm. in phase iii studies, engraftment after high-dose therapy has been comparable to g-csf mobilized patients. the pre-emptive use of plerixafor added to mobilization with chemotherapy plus g-csf or with g-csf alone has gained more popularity. this approach may be more cost-effecti

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Author

Esa Jantunen; Ville Varmavuo; Jaakko Valtola

Publisher

Informa UK Limited

Published

2016

Language

EN

Field

Medicine (Health Sciences)