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Can I read Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats on EtoBox?
Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats by Chon Kit Pun; Hui-Chun Huang; Ching-Chih Chang; Chiao-Lin Chuang; Chun-Hsien Yen; Shao-Jung Hsu; Fa-Yauh Lee; Ming-Chih Hou; Yi-Hsiang Huang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats about?
Portal hypertension develops along with liver cirrhosis then induces the formation of portal-systemic collaterals and lethal complications. Extrahepatic angiogenesis plays an important role. Glycyrrhizin has been found to exhibit anti-angiogenic features, which leads to its extensive use. However, the relevant effects of glycyrrhizin on liver cirrhosis and portal hypertension have not been evaluated. This study thus aimed to investigate the impact of glycyrrhizin on portal hypertension-related derangements in cirrhotic rats. Male Sprague-Dawley rats received bile duct ligation (BDL) to induce cirrhosis or sham operation as control. The rats were subdivided to receive glycyrrhizin (150 mg/kg/day, oral gavage) or vehicle beginning on the 15th day post operation, when BDL-induced liver fibrosis developed. The effects of glycyrrhizin were determined on the 28th day, the typical timing of BDL-induced cirrhosis. Glycyrrhizin significantly reduced portal pressure (__p__ = 0.004). The splanchnic inflow as measured by superior mesenteric arterial flow decreased by 22% (__p__ = 0.029). The portal-systemic collateral shunting degree reduced by 30% (__p__ = 0.024). The mesenteric angiogenesis
Who reads Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Chon Kit Pun; Hui-Chun Huang; Ching-Chih Chang; Chiao-Lin Chuang; Chun-Hsien Yen; Shao-Jung Hsu; Fa-Yauh Lee; Ming-Chih Hou; Yi-Hsiang Huang
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)