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Different Effects of Genistein on Molecular Markers Related to Apoptosis in Two Phenotypically Dissimilar Breast Cancer Cell Lines by Jing Xu; George Loo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Different Effects of Genistein on Molecular Markers Related to Apoptosis in Two Phenotypically Dissimilar Breast Cancer Cell Lines about?
## Abstract The association between consumption of genistein‐containing soybean products and lower risk of breast cancer suggests a cancer chemopreventive role for genistein. Consistent with this suggestion, exposing cultured human breast cancer cells to genistein inhibits cell proliferation, although this is not completely understood. To better understand how genistein works, the ability of genistein to induce apoptosis was compared in phenotypically dissimilar MCF‐7 and MDA‐MB‐231 human breast cancer cells that express the wild‐type and mutant __p53__ gene, respectively. After 6 days of incubation with 50 μM genistein, MCF‐7 but not MDA‐MB‐231 cells, showed morphological signs of apoptosis. Marginal proteolytic cleavage of poly‐(ADP‐ribose)‐polymerase and significant DNA fragmentation were also detected in MCF‐7 cells. In elucidating these findings, it was determined that after 2 days of incubation with genistein, MCF‐7 but not MDA‐MB‐231 cells, had significantly higher levels of p53. Accordingly, the expression of certain proteins modulated by __p53__ was studied next. Levels of __p21__ increased in both of the genistein‐treated cell lines, suggesting that __p21__ gene expressio
Who reads Different Effects of Genistein on Molecular Markers Related to Apoptosis in Two Phenotypically Dissimilar Breast Cancer Cell Lines?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jing Xu; George Loo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)