Can I read A genome-wide association study of osteochondritis dissecans in the Thoroughbred on EtoBox?
A genome-wide association study of osteochondritis dissecans in the Thoroughbred by Laura J. Corbin; Sarah C. Blott; June E. Swinburne; Charlene Sibbons; Laura Y. Fox-Clipsham; Maud Helwegen; Tim D. H. Parkin; J. Richard Newton; Lawrence R. Bramlage; C. Wayne McIlwraith; Stephen C. Bishop; John A. Woolliams; Mark Vaudin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A genome-wide association study of osteochondritis dissecans in the Thoroughbred about?
Osteochondrosis is a developmental orthopaedic disease that occurs in horses, other livestock species, companion animal species, and humans. The principal aim of this study was to identify quantitative trait loci (QTL) associated with osteochondritis dissecans (OCD) in the Thoroughbred using a genome-wide association study. A secondary objective was to test the effect of previously identified QTL in the current population. Over 300 horses, classified as cases or controls according to clinical findings, were genotyped for the Illumina Equine SNP50 BeadChip. An animal model was first implemented in order to adjust each horse's phenotypic status for average relatedness among horses and other potentially confounding factors which were present in the data. The genome-wide association test was then conducted on the residuals from the animal model. A single SNP on chromosome 3 was found to be associated with OCD at a genome-wide level of significance, as determined by permutation. According to the current sequence annotation, the SNP is located in an intergenic region of the genome. The effects of 24 SNPs, representing QTL previously identified in a sample of Hanoverian Warmblood horses,
Who reads A genome-wide association study of osteochondritis dissecans in the Thoroughbred?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Laura J. Corbin; Sarah C. Blott; June E. Swinburne; Charlene Sibbons; Laura Y. Fox-Clipsham; Maud Helwegen; Tim D. H. Parkin; J. Richard Newton; Lawrence R. Bramlage; C. Wayne McIlwraith; Stephen C. Bishop; John A. Woolliams; Mark Vaudin
- Publisher
- Springer Science and Business Media LLC
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)