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The Effects of Mitochondrial Transplantation in Acetaminophen-induced Liver Toxicity in Rats by Oner Ulger; Gokhan Burcin Kubat; Zehra Cicek; Ertugrul Celik; Ozbeyen Atalay; Serpil Suvay; Mehmet Ozler is a Neuroscience article available to read on EtoBox.

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## Aims: Acetaminophen (apap) toxicity is one of the leading causes of acute liver injury-related death and liver failure worldwide. in many studies, mitochondrial dysfunction has been identified as an important cause of damage in apap toxicity. therefore, our study aimed to investigate the possible effects of mitochondrial transplantation on liver damage due to apap toxicity. ## Main methods: Apap toxicity model was implemented by administering a toxic dose of apap. to demonstrate the efficiency of mitochondria transplantation, it was compared with n-acetylcysteine (nac) application, which is now clinically accepted. mitochondrial transplantation was carried out by delivering mitochondria to the liver via the portal circulation, which was injected into the spleen. in our study, the rats were randomly divided into 6 groups as sham, apap, control 1, apap+mito, control 2, and apap+nac. in the end of the experiment, histological and biochemical analysis were performed and the biodistribution of the transplanted mitochondria to target cells were also shown. ## Key findings: Successful mitochondrial transplantation was confirmed and mitochondrial transplantation improved the liver histo

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Author

Oner Ulger; Gokhan Burcin Kubat; Zehra Cicek; Ertugrul Celik; Ozbeyen Atalay; Serpil Suvay; Mehmet Ozler

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)