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Selective cortical infarction reduces [3H]sulpiride binding in rat caudate-putamen: Autoradiographic evidence for presynaptic D2 receptors on corticostriate terminals by F. Filloux; T. H. Liu; C. Y. Hsu; M. A. Hunt; James K. Wamsley is a Neuroscience article available to read on EtoBox.

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Although the existence of presynaptic D2 dopamine receptors on corticostriate terminals has been supported by numerous receptor-binding studies, recent autoradiographic data has failed to demonstrate loss of striatal D2 receptors following cortical lesions. In the present study, Long-Evans rats were subjected to unilateral middle cerebral artery (MCA) infarction in order to produce reproducible lesions of the neocortex without damaging subcortical structures. Animals were sacrificed 2 and 4 wk following lesion and brains were prepared for receptor autoradiography. D2 receptors were studied using the selective ligand 13H]sulpiride, while D1 dopamine receptors were examined using r3H]SCH 23390. Sodium-dependent, high-afhity choline uptake sites were labeled with [3H]hemicholinium-3, thereby providing a quantitative measure of cholinergic neuronal integrity. Unilateral cortical infarction resulted in approximately a 20% reduction in [3H]sulpiride binding in several discrete regions of the ipsilateral caudate-putamen (CPu), but not in the nucleus accumbens. D2 receptor binding was also reduced significantly in some areas of the contralateral CPu when compared with [3H]sulpiride binding

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Author

F. Filloux; T. H. Liu; C. Y. Hsu; M. A. Hunt; James K. Wamsley

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1988

Language

EN

Field

Neuroscience (Life Sciences)