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Low-dose total skin electron beam therapy combined with mogamulizumab for refractory mycosis fungoides and Sézary syndrome by Fong, Sophia ;Hong, Eric K. ;Khodadoust, Michael S. ;Li, Shufeng ;Hoppe, Richard T. ;Kim, Youn H. ;Hiniker, Susan M. is a Medicine article available to read on EtoBox.

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## Purpose Management of patients with refractory mycosis fungoides and Sézary syndrome (SS) is often challenging, as available therapies lack durable response and consistent activity across disease compartments. Combining low-dose total skin electron beam therapy (LD-TSEBT) upfront with mogamulizumab could optimize the clinical outcome of these patients. LD-TSEBT is effective in clearing skin disease, and mogamulizumab is an antitumor immunotherapy with long-term tolerability, suggesting its potential as a maintenance therapy after maximal response. We examine the combination regimen in patients with SS who were previously treated. ## Methods and Materials Two patients with SS were treated with combination LD-TSEBT and mogamulizumab. Both patients received mogamulizumab 1 mg/kg weekly × 4 and then bi-weekly; LD-TSEBT (12 Gy) was initiated within 2 days of starting mogamulizumab and given over 2-3 weeks. Safety and clinical response were evaluated. ## Results Total skin electron beam therapy plus mogamulizumab (TSE-Moga) was well-tolerated without any unanticipated adverse events. Patient 1 (T4N2bM0B2) was a 63-year-old woman with 4 prior systemic therapies; time to global response

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Author

Fong, Sophia ;Hong, Eric K. ;Khodadoust, Michael S. ;Li, Shufeng ;Hoppe, Richard T. ;Kim, Youn H. ;Hiniker, Susan M.

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)