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Cloning of human and murine TER1, an orphan chemokine receptor expressed by lymphoid tissues, and CHR3 a seven transmembrane spanning receptor by A. Zingoni; G. Bernardini; G. Spinetti; A. Nista; C.T. Storlazzi; M. Rocchi; A. Santoni; M. Napolitano is a Immunology and Microbiology article available to read on EtoBox.

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## Intmductlon: The lesions induced by potentially oncogenic ("high risk") HPV types usually regress. However, a small proportion of lesions persists and may undergo malignant conversion. The mechanisms responsible for regression or malignant progression of HPV-associated lesions are still poorly recognized. Regression is mediated by inflttrating lymphocytes and monocytes. Thus, recruitment of lymphoid cells to the lesion may be a crucial step in rejection of HPVtransformed keratinocytes. Accumulation of lymphoid cells at site of immunological reaction depends on local production of chemotactic factors, especially chemoklnes. Therefore, the aim of our present study was to evaluate expression and production of various chemokines by different keratinocyte/epithelial cell lines harboring and expressing HPV16 DNA sequences. Mat&al and Methods: The study was performed on tumotigenic HPVl6-harbortng SKv, SiHa, and CaSki cell lines and nontumorigenic HaCaT keratinccyte cell line which does not contain HPV. The presence of MCP-1, RANTES, and IL-8 in cell-free culture supematants was evaluated by specific ELISA and Western blot analysis. Expression of specific chemokine mRNAs was analyzed b

Who reads Cloning of human and murine TER1, an orphan chemokine receptor expressed by lymphoid tissues, and CHR3 a seven transmembrane spanning receptor?

Author

A. Zingoni; G. Bernardini; G. Spinetti; A. Nista; C.T. Storlazzi; M. Rocchi; A. Santoni; M. Napolitano

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)