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A kinetic model describing Shewanella oneidensis MR-1 growth, substrate consumption, and product secretion by Yinjie J. Tang; Adam L. Meadows; Jay D. Keasling is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract Aerobic growth of __Shewanella oneidensis__ MR‐1 in minimal lactate medium was studied in batch cultivation. Acetate production was observed in the middle of the exponential growth phase and was enhanced when the dissolved oxygen (DO) concentration was low. Once the lactate was nearly exhausted, __S. oneidensis__ MR‐1 used the acetate produced during growth on lactate with a similar biomass yield as lactate. A two‐substrate Monod model, with competitive and uncompetitive substrate inhibition, was devised to describe the dependence of biomass growth on lactate, acetate, and oxygen and the acetate growth inhibition across a broad range of concentrations. The parameters estimated for this model indicate interesting growth kinetics: lactate is converted to acetate stoichiometrically regardless of the DO concentration; cells grow well even at low DO levels, presumably due to a very low __K__~m~ for oxygen; cells metabolize acetate (maximum specific growth rate, __μ__~max,A~ of 0.28 h^−1^) as a single carbon source slower than they metabolize lactate (__μ__~max,L~ of 0.47 h^−1^); and growth on acetate is self‐inhibiting at a concentration greater than 10 mM. After estimating
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- Author
- Yinjie J. Tang; Adam L. Meadows; Jay D. Keasling
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 0006-3592)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)