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Genetic diversity of Formosan pangolins (Manis pentadactyla pentadactyla) in Taiwan based on the MHC gene by Jin-Ting Liu; Fang-Yu Lai; Hsuan Wu; Flora Hsuan-Yi Lo; En-Chung Lin; Eric Hsien-Shao Taso; Pei-Hwa Wang is a scholarly article available to read on EtoBox.

What is Genetic diversity of Formosan pangolins (Manis pentadactyla pentadactyla) in Taiwan based on the MHC gene about?

Abstract The Formosan pangolin (Manis pentadactyla pentadactyla) is an endangered species in Taiwan. Usually, a decline in population size leads to a decrease in genetic diversity and increases the risk of extinction. Thus, measuring genetic diversity of Formosan pangolins in Taiwan is important in conservation programs. The major histocompatibility complex (MHC) genes play a crucial role in the immune response in many animals. Therefore, polymorphisms at these gene regions could provide an indicator for the immunological fitness of a population. In this study, seven different novel markers for MHC genotyping of Formosan pangolin were developed. In total, 92 Formosan pangolins from throughout Taiwan were collected and used to evaluate their genetic diversity. In the MHC markers, six loci showed monomorphism or only two haplotypes. Only one marker, a DLA class II DR-1 beta chain-like locus, showed more diversity: four haplotypes were detected and their relative frequencies were 62.0, 37.0, 0.5 and 0.5%, with nine polymorphic sites in the nucleotide sequence and six variable sites in the amino acid sequence. Moreover, the non-synonymous substitution rate (dN) and synonymous substitut

Author

Jin-Ting Liu; Fang-Yu Lai; Hsuan Wu; Flora Hsuan-Yi Lo; En-Chung Lin; Eric Hsien-Shao Taso; Pei-Hwa Wang

Published

2022

Language

EN