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Can I read Metagenomic Evidence for Antibiotics-driven Co-evolution of Microbial Community, Resistome and Mobilome in Hospital Sewage on EtoBox?
Metagenomic Evidence for Antibiotics-driven Co-evolution of Microbial Community, Resistome and Mobilome in Hospital Sewage by Jiayu Sun; Yumeng Yuan; Leshan Cai; Mi Zeng; Xin Li; Fen Yao; Weidong Chen; Yuanchun Huang; Muhammad Shafiq; Qingdong Xie; Qiaoxin Zhang; Naikei Wong; Zhen Wang; Xiaoyang Jiao is a Environmental Science article available to read on EtoBox.
What is Metagenomic Evidence for Antibiotics-driven Co-evolution of Microbial Community, Resistome and Mobilome in Hospital Sewage about?
Overconsumption of antibiotics is an immediate cause for the emergence of antimicrobial resistance (AMR) and antibiotic resistant bacteria (ARB), though its environmental impact remains inadequately clarified. There is an urgent need to dissect the complex links underpinning the dynamic co-evolution of ARB and their resistome and mobilome in hospital sewage. Metagenomic and bioinformatic methods were employed to analyze the microbial community, resistome and mobilome in hospital sewage, in relation to data on clinical antibiotic use collected from a tertiary-care hospital. In this study, resistome (1,568 antibiotic resistance genes, ARGs, corresponding to 29 antibiotic types/subtypes) and mobilome (247 types of mobile genetic elements, MGEs) were identified. Networks connecting co-occurring ARGs with MGEs encompass 176 nodes and 578 edges, in which over 19 types of ARGs had significant correlations with MGEs. Prescribed dosage and time-dependent antibiotic consumption were associated with the abundance and distributions of ARGs, and conjugative transfer of ARGs via MGEs. Variation partitioning analyses show that effects of conjugative transfer were most likely the main contributors
Who reads Metagenomic Evidence for Antibiotics-driven Co-evolution of Microbial Community, Resistome and Mobilome in Hospital Sewage?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Jiayu Sun; Yumeng Yuan; Leshan Cai; Mi Zeng; Xin Li; Fen Yao; Weidong Chen; Yuanchun Huang; Muhammad Shafiq; Qingdong Xie; Qiaoxin Zhang; Naikei Wong; Zhen Wang; Xiaoyang Jiao
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)