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Weighting Based Approaches to Borrowing Historical Controls for Indirect comparison for Time-to-Event Data with a Cure Fraction by Wang, Jixian; Zhang, Hongtao; Tiwari, Ram is a scholarly article available to read on EtoBox.

What is Weighting Based Approaches to Borrowing Historical Controls for Indirect comparison for Time-to-Event Data with a Cure Fraction about?

To use historical controls for indirect comparison with single-arm trials, the population difference between data sources should be adjusted to reduce confounding bias. The adjustment is more difficult for time-to-event data with a cure fraction. We propose different adjustment approaches based on pseudo observations and calibration weighting by entropy balancing. We show a simple way to obtain the pseudo observations for the cure rate and propose a simple weighted estimator based on them. Estimation of the survival function in presence of a cure fraction is also considered. Simulations are conducted to examine the proposed approaches. An application to a breast cancer study is presented.

Author

Wang, Jixian; Zhang, Hongtao; Tiwari, Ram

Published

2023

Language

EN