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Control of the Molecular Degradation of Hyaluronic Acid Hydrogels for Tissue Augmentation by Eun Ju Oh; Sun‐Woong Kang; Byung‐Soo Kim; Ge Jiang; Il Hwan Cho; Sei Kwang Hahn is a Engineering article available to read on EtoBox.

What is Control of the Molecular Degradation of Hyaluronic Acid Hydrogels for Tissue Augmentation about?

## Abstract A novel protocol to control the molecular degradation of hyaluronic acid (HA) hydrogels was successfully developed for tissue augmentation applications. HA has a different conformational structure in water and organic solvent, and the carboxyl group of HA is known to be the recognition site of hyaluronidase and HA receptors. Based on these findings, HA was chemically modified by grafting adipic acid dihydrazide (ADH) to the carboxyl group of HA in the water to prepare HA‐ADH~WATER~ and in the mixed solvent of water and ethanol to prepare degradation‐controlled HA‐ADH~WATER/ETHANOL~. Three kinds of HA hydrogels were prepared by the crosslinking of HA‐ADH~WATER~ or HA‐ADH~WATER/ETHANOL~ with bis(sulfosuccinimidyl) suberate, and by the crosslinking of HA‐OH with divinyl sulfone (DVS). __In vitro__ and __in vivo__ degradation tests showed that HA‐DVS hydrogels were degraded most rapidly, followed by HA‐ADH~WATER~ hydrogels and HA‐ADH~WATER/ETHANOL~ hydrogels. There was no adverse effect during and after __in vivo__ degradation tests. All of the HA hydrogel samples appeared to be biocompatible, according to the histological analysis with hematoxylin–eosin and Alcian blue. ©

Who reads Control of the Molecular Degradation of Hyaluronic Acid Hydrogels for Tissue Augmentation?

Author

Eun Ju Oh; Sun‐Woong Kang; Byung‐Soo Kim; Ge Jiang; Il Hwan Cho; Sei Kwang Hahn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2007

Language

EN

Field

Engineering (Physical Sciences)