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Detection of counterfeit antiviral drug HeptodinTM and classification of counterfeits using isotope amount ratio measurements by multicollector inductively coupled plasma mass spectrometry (MC-ICPMS) and isotope ratio mass spectrometry (IRMS) by Rebeca Santamaria-Fernandez; Ruth Hearn; Jean-Claude Wolff is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Detection of counterfeit antiviral drug HeptodinTM and classification of counterfeits using isotope amount ratio measurements by multicollector inductively coupled plasma mass spectrometry (MC-ICPMS) and isotope ratio mass spectrometry (IRMS) about?

Isotope ratio mass spectrometry (IRMS) and multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS) are highly important techniques that can provide forensic evidence that otherwise would not be available. MC-ICP-MS has proved to be a very powerful tool for measuring high precision and accuracy isotope amount ratios. In this work, the potential of combining isotope amount ratio measurements performed by MC-ICP-MS and IRMS for the detection of counterfeit pharmaceutical tablets has been investigated. An extensive study for the antiviral drug Heptodin has been performed for several isotopic ratios combining MC-ICP-MS and an elemental analyser EA-IRMS for stable isotope amount ratio measurements. The study has been carried out for 139 batches of the antiviral drug and analyses have been performed for C, S, N and Mg isotope ratios. Authenticity ranges have been obtained for each isotopic system and combined to generate a unique multi-isotopic pattern only present in the genuine tablets. Counterfeit tablets have then been identified as those tablets with an isotopic fingerprint outside the genuine isotopic range. The combination of those two techniques has therefore great

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Author

Rebeca Santamaria-Fernandez; Ruth Hearn; Jean-Claude Wolff

Publisher

Elsevier Science; Elsevier ; Forensic Science Society; Elsevier BV (ISSN 1355-0306)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Social Sciences)