Can I read Oral Behaviour Induced by Intranigral Muscimol Is Unaffected by Haloperidol but Abolished by Large Lesions of Superior Colliculus on EtoBox?

Oral Behaviour Induced by Intranigral Muscimol Is Unaffected by Haloperidol but Abolished by Large Lesions of Superior Colliculus by E. B. Taha; P. Dean; P. Redgrave is a Neuroscience article available to read on EtoBox.

What is Oral Behaviour Induced by Intranigral Muscimol Is Unaffected by Haloperidol but Abolished by Large Lesions of Superior Colliculus about?

It has been suggested that the GABAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We report here two experiments on this effect: (1) A dose of the dopamine receptor blocker haloperidol (0.4mg/kg), which effectively antagonised oral stereotypy induced by systemically administered apomorphine or intranigral carbachot, had no effect on either the latency or the intensity of the gnawing produced by intranigral muscimol (1 nM); (2) large lesions involving the superior colliculus which effectively suppressed the oral stereotypy induced by 8mg/kg apomorphine completely abolished the gnawing induced by intranigral injection of muscimol. Collicular lesions suppressed both the gnawing which occurred spontaneously and that elicited by a perioral probe. These findings are consistent with the view that the substantia nigra is a relay station between the caudate nucleus and the superior colliculus in an efferent pathway mediating dopamine-related oral behaviour. In add

Who reads Oral Behaviour Induced by Intranigral Muscimol Is Unaffected by Haloperidol but Abolished by Large Lesions of Superior Colliculus?

Author

E. B. Taha; P. Dean; P. Redgrave

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1982

Language

EN

Field

Neuroscience (Life Sciences)