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Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1 ^–/–^mice by Miroslava Kvandova; Konstantina Filippou; Sebastian Steven; Matthias Oelze; Sanela Kalinovic; Paul Stamm; Katie Frenis; Ksenija Vujacic-Mirski; Kunihiko Sakumi; Yusaku Nakabeppu; Majid Bagheri Hosseinabadi; Ima Dovinova; Bernd Epe; Thomas Münzel; Swenja Kröller-Schön; Andreas Daiber is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1 ^–/–^mice about?
Background: Large epidemiological studies point towards a link between the incidence of arterial hypertension, ischaemic heart disease, metabolic disease and exposure to traffic noise, supporting the role of noise exposure as an independent cardiovascular risk factor. We characterised the underlying molecular mechanisms leading to noise-dependent adverse effects on the vasculature and myocardium in an animal model of aircraft noise exposure and identified oxidative stress and inflammation as central players in mediating vascular and cardiac dysfunction. Here, we studied the impact of noise-induced oxidative DNA damage on vascular function in DNArepair deficient 8-oxoguanine glycosylase knockout (Ogg1 -/-) mice. Methods and results: Noise exposure (peak sound levels of 85 and mean sound level of 72 dB(A) applied for 4d) caused oxidative DNA damage (8-oxoguanine) and enhanced NOX-2 expression in C57BL/6 mice with synergistic increases in Ogg1 -/-mice (shown by immunohistochemistry). A similar pattern was found for oxidative burst of blood leukocytes and other markers of oxidative stress (4-hydroxynonenal, 3-nitrotyrosine) and inflammation (cyclooxygenase-2). We observed additive impa
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It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Miroslava Kvandova; Konstantina Filippou; Sebastian Steven; Matthias Oelze; Sanela Kalinovic; Paul Stamm; Katie Frenis; Ksenija Vujacic-Mirski; Kunihiko Sakumi; Yusaku Nakabeppu; Majid Bagheri Hosseinabadi; Ima Dovinova; Bernd Epe; Thomas Münzel; Swenja Kröller-Schön; Andreas Daiber
- Publisher
- Informa plc; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 1071-5762)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)