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Decarboxylative 1,4-Addition of α-Oxocarboxylic Acids with Michael Acceptors Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases by Jinlong Zhou; Zhelun Wang; Zuojun Shen; Xiaolong Liu is a Engineering article available to read on EtoBox.

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We report herein a metal-free method to perform Giese radical addition through photoactivation of flavin-dependent enzymes. The reaction presents a sustainable method to construct carbon−carbon bonds and produce products in water with a broad substrate scope and functional group compatibility under mild blue light irradiation conditions without the cofactor cycle system popularly used. This is the first report of the application of "ene"-reductase to photocatalytic decarboxylation for C−C bond construction reaction.

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Author

Jinlong Zhou; Zhelun Wang; Zuojun Shen; Xiaolong Liu

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN

Field

Engineering (Physical Sciences)