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Synthesis of Deuterium-labelled Methylphenidate, P-hydroxymethylphenidate, Ritalinic Acid and P-hydroxyritalinic Acid by Kennerly Patrick; Clinton Kilts; George Breese is a Chemistry article available to read on EtoBox.

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## Abstract The synthesis of __threo__‐dl‐methylphenidate (Ritalin^®^, __1__), __threo__‐dl‐p‐hydroxymethylphenidate (__3__), __threo__‐dl‐ritalinic acid (__2__), and __threo__‐dl‐p‐hydroxyritalinic acid (__4__) with deuterium incorporated in the piperidine ring is described. These compounds were synthesized for use as internal standards for mass fragmentographic assays of methylphenidate and its metabolites. The synthetic scheme described resulted in less than 0.05% ^2^H~0~ in the piperidine ring in any of the preparations.

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Author

Kennerly Patrick; Clinton Kilts; George Breese

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

1982

Language

EN

Field

Chemistry (Life Sciences)