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Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis by Yeon-Sook Choi; Myung Ji Kim; Eun A. Choi; Sinae Kim; Eun ji Lee; Min Ji Park; Mi-Ju Kim; Yeon Wook Kim; Hee-Sung Ahn; Jae Yun Jung; Gayoung Jang; Yongsub Kim; Hyori Kim; Kyunggon Kim; Jin Young Kim; Seung-Mo Hong; Song Cheol Kim; Suhwan Chang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis about?
## Significance Pancreatic ductal adenocarcinoma (PDAC) metastasis is a major cause for poor prognosis; therefore, developing targeted therapeutics is critical for overcoming it. By proteomic analysis of tumor secretome, we identified the galectin-3 binding protein as a druggable target for PDAC metastasis. Further, we developed an antibody for the galectin-3 binding protein and showed that the antibody-mediated blockade is a promising therapeutic strategy for PDAC.
Who reads Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yeon-Sook Choi; Myung Ji Kim; Eun A. Choi; Sinae Kim; Eun ji Lee; Min Ji Park; Mi-Ju Kim; Yeon Wook Kim; Hee-Sung Ahn; Jae Yun Jung; Gayoung Jang; Yongsub Kim; Hyori Kim; Kyunggon Kim; Jin Young Kim; Seung-Mo Hong; Song Cheol Kim; Suhwan Chang
- Publisher
- Proceedings of the National Academy of Sciences
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)