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Can I read Combination Therapy of Obeticholic Acid and Ursodeoxycholic Acid in Patients with Primary Biliary Cholangitis Who Respond Incompletely to Ursodeoxycholic Acid: a Systematic Review on EtoBox?
Combination Therapy of Obeticholic Acid and Ursodeoxycholic Acid in Patients with Primary Biliary Cholangitis Who Respond Incompletely to Ursodeoxycholic Acid: a Systematic Review by Xuan Li; Min Liao; Qiong Pan; Qiaoling Xie; Hong Yang; Ying Peng; Qiao Li; Jiaquan Qu; Jin Chai is a Medicine article available to read on EtoBox.
What is Combination Therapy of Obeticholic Acid and Ursodeoxycholic Acid in Patients with Primary Biliary Cholangitis Who Respond Incompletely to Ursodeoxycholic Acid: a Systematic Review about?
## Background: Although the efficacy of ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) for primary biliary cholangitis (PBC) has been suggested by small trials, a meta-analysis to summarize the evidence has not yet been carried out. The aim of this study was to evaluate the clinical outcomes of the combination therapy of UDCA and OCA compared with UDCA monotherapy in patients with PBC. ## Methods and materials: We searched the PubMed, EMBASE, the web of science, and the Cochrane Library databases for English-language studies published before September 2018. Studies were included if they were randomized controlled trials (RCTs) and reported relative risk (RR) estimates with 95% confidence intervals (CIs) or related data for the clinical outcomes of different therapies in patients with PBC. ## Results: Of the 1169 titles identified, two studies meeting the inclusion criteria were included in the meta-analysis. Approximately 222 patients with PBC were included in this analysis. The results of this study indicated that combination therapy was significantly superior to monotherapy in reducing serum alanine transaminase (mean difference: –15.63 IU/L; 95% CI, –21.59 to –9.68), asp
Who reads Combination Therapy of Obeticholic Acid and Ursodeoxycholic Acid in Patients with Primary Biliary Cholangitis Who Respond Incompletely to Ursodeoxycholic Acid: a Systematic Review?
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- Author
- Xuan Li; Min Liao; Qiong Pan; Qiaoling Xie; Hong Yang; Ying Peng; Qiao Li; Jiaquan Qu; Jin Chai
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)