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Monoamine oxidase A imaging in peripheral organs in healthy human subjects by Joanna S. Fowler; Jean Logan; Gene‐Jack Wang; Dinko Franceschi; Nora D. Volkow; Frank Telang; Naomi Pappas; Richard Ferrieri; Colleen Shea; Victor Garza; Youwen Xu; Payton King; David Schlyer; S. John Gatley; Yu‐Shin Ding; Donald Warner; Noelwah Netusil; Pauline Carter; Millard Jayne; David Alexoff; Wei Zhu; Paul Vaska is a Neuroscience article available to read on EtoBox.
What is Monoamine oxidase A imaging in peripheral organs in healthy human subjects about?
## Abstract Monoamine oxidase (MAO) catalyzes the oxidative deamination of many biogenic and dietary amines. Though studies of MAO have focused mainly on its regulatory role in the brain, MAO in peripheral organs also represents a vast mechanism for detoxifying vasoactive compounds as well as for terminating the action of physiologically active amines, which can cross the blood brain barrier. Indeed, robust central and peripheral MAO activity is a major requirement in the safe use of many CNS drugs, particularly antidepressants, and thus an awareness of the MAO inhibitory potential of drugs is essential in therapeutics. In this study, we examined the feasibility of quantifying MAO A in peripheral organs in healthy human subjects using comparative positron emission tomography (PET) imaging with carbon‐11 (t~1/2~: 20.4 min) labeled clorgyline ([^11^C]clorgyline) a suicide inactivator of MAO A and its deuterium labeled counterpart ([^11^C]clorgyline‐D2). Heart, lungs, kidneys, thyroid, and spleen showed a robust deuterium isotope effect characteristic of MAO and the magnitude of the effect was similar to that of trancylcypromine, an irreversible MAO inhibitor used in the treatment of
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It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Joanna S. Fowler; Jean Logan; Gene‐Jack Wang; Dinko Franceschi; Nora D. Volkow; Frank Telang; Naomi Pappas; Richard Ferrieri; Colleen Shea; Victor Garza; Youwen Xu; Payton King; David Schlyer; S. John Gatley; Yu‐Shin Ding; Donald Warner; Noelwah Netusil; Pauline Carter; Millard Jayne; David Alexoff; Wei Zhu; Paul Vaska
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)