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Zinc Burden Evokes Copper Deficiency in the Hypoalbuminemic Hemodialysis Patients by Nishime, Keizo; Kondo, Morihiro; Saito, Kazuhiro; Miyawaki, Hisashi; Nakagawa, Takahiko is a Medicine article available to read on EtoBox.

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Background: Recent research has focused on the roles of trace minerals such as zinc and copper. In 2017, oral zinc acetate was approved to treat zinc deficiency, and the next year, the Japanese Society for Clinical Nutrition developed the guidelines for diagnosis and treatment for zinc deficiency. Accordingly, hemodialysis patients began receiving zinc acetate when zinc deficiency was diagnosed. However, studies regarding the values of zinc and copper in hemodialysis patients are extremely poor, thus it remains unclear if the guidelines for healthy subjects can be applied to hemodialysis patients. Methods: We conducted a descriptive study, in which 132 patients were subjected to simply examine serum zinc concentration and its association with copper levels in hemodialysis patients (__N__ = 65) versus healthy individuals attending a routine check-up (control group; __N__ = 67) in our hospital. Analyses were performed with BellCurve for Excel (Social Survey Research Information Co., Ltd. Tokyo, Japan). Results: The distribution of zinc level in the hemodialysis group was distinct from that in the control group (__P__ < 0.001). The zinc level was correlated with serum albumin concentr

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Author

Nishime, Keizo; Kondo, Morihiro; Saito, Kazuhiro; Miyawaki, Hisashi; Nakagawa, Takahiko

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2009-; Publons; Research Square (ISSN 2072-6643)

Published

2020

Language

EN

Field

Medicine (Health Sciences)