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Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis by Matthew G. Davey; Martin S. Davey; Michael R. Boland; Éanna J. Ryan; Aoife J. Lowery; Michael J. Kerin is a Medicine article available to read on EtoBox.
What is Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis about?
## Introduction: Breast cancer has four distinct molecular subtypes which are discriminated using gene expression profiling following biopsy. radiogenomics is an emerging field which utilises diagnostic imaging to reveal genomic properties of disease. we aimed to perform a systematic review of the current literature to evaluate the value radiomics in differentiating breast cancers into their molecular subtypes using diagnostic imaging. ## Methods: A systematic review was performed as per prisma guidelines. studies assessing radiomictumour analysis in differentiatingbreast cancer molecular subtypeswere included. quality was assessed using the radiomics quality score (rqs). diagnostic sensitivity and specificity of radiomic analyses were included for meta-analysis; study specific sensitivity and specificity were retrieved and summary roc analysis were performed to compile pooled sensitivities and specificities. ## Results: Forty-one studies were included. overall, there were 10,090 female patients (mean age of 47.6 ± 11.7 years, range: 21-93) and molecular subtypewas reported in 7,693 of cases, with luminal a (labc), luminal b (lbbc), human epidermal growth factor receptor-2 overexpr
Who reads Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis?
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- Author
- Matthew G. Davey; Martin S. Davey; Michael R. Boland; Éanna J. Ryan; Aoife J. Lowery; Michael J. Kerin
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)