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Prostate Specific Antigen Density to Predict Prostate Cancer Upgrading in a Contemporary Radical Prostatectomy Series: A Single Center Experience by Ahmed Magheli; Stefan Hinz; Claudia Hege; Carsten Stephan; Klaus Jung; Kurt Miller; Michael Lein is a Medicine article available to read on EtoBox.
What is Prostate Specific Antigen Density to Predict Prostate Cancer Upgrading in a Contemporary Radical Prostatectomy Series: A Single Center Experience about?
## Purpose: We investigated the value of pretreatment prostate specific antigen density to predict gleason score upgrading in light of significant changes in grading routine in the last 2 decades. ## Materials and methods: Of 1,061 consecutive men who underwent radical prostatectomy between 1999 and 2004, 843 were eligible for study. prostate specific antigen density was calculated and a cutoff for highest accuracy to predict gleason upgrading was determined using roc curve analysis. the predictive accuracy of prostate specific antigen and prostate specific antigen density to predict gleason upgrading was evaluated using roc curve analysis based on predicted probabilities from logistic regression models. ## Results: Prostate specific antigen and prostate specific antigen density predicted gleason upgrading on univariate analysis (as continuous variables or 1.07 and 7.21, each p <0.001) and on multivariate analysis (as continuous variables with prostate specific antigen density adjusted for prostate specific antigen or 1.07, p <0.001 and or 4.89, p = 0.037, respectively). when prostate specific antigen density was added to the model including prostate specific antigen and other glea
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- Author
- Ahmed Magheli; Stefan Hinz; Claudia Hege; Carsten Stephan; Klaus Jung; Kurt Miller; Michael Lein
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)