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Observational study to evaluate the safety and efficacy of saroglitazar in Indian diabetic dyslipidemia patients by Sadanand R. Shetty; Soumitra Kumar; R.P. Mathur; Kamal H. Sharma; Ashok D. Jaiswal is a Medicine article available to read on EtoBox.

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Saroglitazar is a dual PPAR α/γ agonist approved in India for the management of diabetic dyslipidemia. ## Aims: The objective of this study was to evaluate the safety and efficacy of saroglitazar 4 mg once daily in clinical practice. ## Methods: This was an observational, multicenter, single-arm study. patients with type 2 diabetes (with on-going antidiabetic medication), age above 18 years, and triglycerides ≥200 mg/dl were included. ## Results: A total 2804 patients with a mean duration of diabetes 6.29 yrs were included in this analysis. the baseline demographic profile was: mean age of 53 yrs, mean body weight 72.3 kg and mean bmi of 27 kg/m(2). 62.5% patients were male and 57.8% were reported to be on statin therapy at baseline. all 2804 patients were on antidiabetic medications with 15.4% patients on monotherapy and rest were on two or more than two antidiabetic medications at baseline. the baseline triglycerides and hba1c values were 312.3 mg/dl and 8.3% respectively. at 3 months follow-up, use of saroglitazar 4 mg led to significant reduction in tg (35.8%), ldl-c (16.4%), total cholesterol (19%) and non-hdl-c (23.4%). addition of saroglitazar to baseline antidiabetic medica

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Author

Sadanand R. Shetty; Soumitra Kumar; R.P. Mathur; Kamal H. Sharma; Ashok D. Jaiswal

Published

2015

Language

EN

Field

Medicine (Health Sciences)