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Bone Metabolism in Ochronotic Patients by G. Aliberti; I. Pulignano; A. Schiappoli; S. Minisola; E. Romagnoli; M. Proietta is a Medicine article available to read on EtoBox.

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**Abstract.** Aliberti G, Pulignano I, Schiappoli A, Minisola S, Romagnoli E, Proietta M (Università di Roma ‘La Sapienza’, Rome, Italy). Bone metabolism in ochronotic patients (Case report). __J Intern Med__ 2003; **254:** 296–300. We investigated skeletal involvement in five male and two female patients with ochronosis, aged 26–82 years. The main parameters of mineral metabolism, together with biochemical markers of bone resorption (urinary N‐telopeptides of type I collagen) and formation (serum bone isoenzyme of alkaline phosphatase and serum osteocalcin) were evaluated. In the same subjects lumbar spine and femoral bone mineral density (BMD) were also measured by dual energy X‐ray absorptiometry. All patients but the younger 26‐year‐old patient had lower than normal bone mass at femoral neck and total hip, showing marked osteopenia in three cases and osteoporosis in the remaining three cases. However, at lumbar spine BMD measurement provided spuriously overestimated results, because of intervertebral disc calcification and osteophyte formation. As far as biochemical markers of bone turnover are concerned, the most relevant finding was the increased N‐telopeptides of type I coll

Who reads Bone Metabolism in Ochronotic Patients?

Author

G. Aliberti; I. Pulignano; A. Schiappoli; S. Minisola; E. Romagnoli; M. Proietta

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-6820)

Published

2003

Language

EN

Field

Medicine (Health Sciences)