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## Bleomycin/doxycycline/sirolimus Pulmonary haemorrhage and lack of efficacy: case report A boy [exact age at the time of reaction onset not stated] exhibited lack of efficacy during treatment with bleomycin, doxycycline and sirolimus for cervicofacial lymphatic malformation (LM). Additionally, he developed pulmonary haemorrhage during treatment with sirolimus for cervicofacial LM [not all routes stated; time to reaction onset not stated]. The boy was transferred to NICU after birth for further evaluation of cervicofacial LM which had been identified prenatally with fetal anterior neck mass. Upon admission to the NICU, sclerotherapy with doxycycline 150mg was initiated on day 6 of life. Sirolimus 0.8 mg/m 2 /day, (0.14mg) oral solution was initiated on day 8 of life. He received doxycycline as weekly dose followed by biweekly dose at 4 x 150mg (day 15-29), 300mg (on day 33), 3 x 300mg (at 1.5 month), 10 x 300mg (at around 2 months) and 7 x 300mg (at around 3 months). Sirolimus dose was gradually increased to 0.18mg (at 2 month), 0.22mg (day 75), 0.3 mg/day (day 83) and 0.4 mg/day (day 118). Sirolimus levels were obtained on a weekly basis, and target levels were maintained. Pneumo

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Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)