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Current ARTs, Virologic Failure, and Implications for AIDS Management: A Systematic Review by Frank Eric Tatsing Foka; Hazel Tumelo Mufhandu is a Medicine article available to read on EtoBox.

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Antiretroviral therapies (ARTs) have revolutionized the management of human immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and reduced the mortality rate and incidence of acquired immunodeficiency syndrome (AIDS). However, despite the remarkable efficacy of ART, virologic failure remains a challenge in the long-term management of HIV-infected individuals. Virologic failure refers to the persistent detectable viral load in patients receiving ART, indicating an incomplete suppression of HIV replication. It can occur due to various factors, including poor medication adherence, drug resistance, suboptimal drug concentrations, drug interactions, and viral factors such as the emergence of drug-resistant strains. In recent years, extensive efforts have been made to understand and address virologic failure in order to optimize treatment outcomes. Strategies to prevent and manage virologic failure include improving treatment adherence through patient education, counselling, and supportive interventions. In addition, the regular monitoring of viral load and resistance testing enables the early detection of treatment failure and facilitates timely adjustments

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Author

Frank Eric Tatsing Foka; Hazel Tumelo Mufhandu

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Health Sciences)