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Early Liver Biopsy, Intraparenchymal Cholestasis, and Prognosis in Patients with Alcoholic Steatohepatitis by Laurent Spahr; Laura Rubbia-Brandt; Muriel Genevay; Antoine Hadengue; Emiliano Giostra is a Medicine article available to read on EtoBox.

What is Early Liver Biopsy, Intraparenchymal Cholestasis, and Prognosis in Patients with Alcoholic Steatohepatitis about?

## Background Alcoholic steatohepatitis (ASH) is a serious complication of alcoholic liver disease. The diagnosis of ASH requires the association of steatosis, evidence of hepatocellular injury with ballooning degeneration, and polynuclear neutrophil infiltration on liver biopsy. Whether these lesions, in addition to other histological features observed in liver tissue specimens, have prognostic significance is unclear. ## Methods We studied 163 patients (age 55 yrs [35-78], male/female 102/61) with recent, heavy (> 80 gr/day) alcohol intake, histologically-proven ASH (97% with underlying cirrhosis, Maddrey's score 39 [13-200], no sepsis), who had a liver biopsy performed 3 days [0-10] after hospital admission for clinical decompensation. A semi-quantitative evaluation of steatosis, hepatocellular damage, neutrophilic infiltration, periportal ductular reaction, intraparenchymal cholestasis, and iron deposits was performed by two pathologists. All patients with a Maddrey's score ≥ 32 received steroids. The outcome at 3 months was determined. Statistical analysis was performed using the Wilcoxon and Fisher's exact tests, Kaplan-Meier method, and the Cox proportional hazard model. ##

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Author

Laurent Spahr; Laura Rubbia-Brandt; Muriel Genevay; Antoine Hadengue; Emiliano Giostra

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-230X)

Published

2011

Language

EN

Field

Medicine (Health Sciences)