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Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride ^1^ by Adriana Yuriko Koga; Julio César Felix; Rodrigo Gomes Marques Silvestre; Leandro Cavalcante Lipinski; Bruna Carletto; Fernanda Alexia Kawahara; Airton Vicente Pereira is a Medicine article available to read on EtoBox.
What is Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride ^1^ about?
## Abstract ## Purpose To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. ## Methods The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Wound contraction measurements and hystological analysis were performed on 7th, 14th and 21st days after wound surgery. ## Results The aloe-alginate film presented adequated mechanical resistance and malleability for application as wound dressing. There was no statistical difference in wound contraction between two groups. Histological assay demonstrated that aloe-alginate film presented anti-inflammatory activity, stimulated angiogenesis on proliferative phase and a more significant increased in collagen type I fibers and decreased type III fibers which promoted a mature scar formation when compared to control. ## Conclusions The aloe-alginate film showed adequate physicochemical characteristics for wound dressing applications. The __in vivo__ assay
Who reads Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride ^1^?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Adriana Yuriko Koga; Julio César Felix; Rodrigo Gomes Marques Silvestre; Leandro Cavalcante Lipinski; Bruna Carletto; Fernanda Alexia Kawahara; Airton Vicente Pereira
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)