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Outcomes of Total Anomalous Pulmonary Venous Drainage Repair in Neonates and the Impact of Pulmonary Hypertension on Survival by Antonia Schulz; Damien M. Wu; Shuta Ishigami; Edward Buratto; Duncan MacGregor; Matthew S. Yong; Yaroslav Ivanov; Roberto Chiletti; Christian P. Brizard; Igor E. Konstantinov is a Medicine article available to read on EtoBox.

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## Background Mortality after repair of total anomalous pulmonary venous drainage (TAPVD) in neonates has remained high. Analysis of risk factors may help identify therapeutic targets to improve survival. ## Methods Retrospective analysis of all neonates who underwent simple TAPVD repair. ## Results Between 1973 and 2021, 175 neonates underwent TAPVD repair, at a median age of 6 days (interquartile range, 2-15 days) and a mean weight of 3.2 ± 0.6 kg. TAPVD was supracardiac in 42.3% of the patients (74 of 175), cardiac in 14.3% (25 of 175), infracardiac in 40% (70 of 175), and mixed type in 3.4% (6 of 175), with obstruction in 65.7% (115 of 175). Pulmonary hypertension (PHT) crisis occurred in 12% (21 of 175). Early mortality was 9.7% (17 of 175) and late mortality was 5.1% (8 of 158), with most deaths occurring within 1 year (75%; 6 of 8). Survival was 86.5% (95% CI, 80.3%-90.8%) at 1 year and 85.8% (95% CI, 79.6%-90.3%) at 5, 10, 15, and 20 years. Survival was lower in patients with obstructed TAPVD, patients with emergent surgery, and those with PHT crisis. PHT crisis (hazard ratio [HR], 4.93; 95% CI, 1.95-12.51; __P__ = .001), urgency of surgery (HR, 2.51; 95% CI, 1.11-5.68; __P

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Author

Antonia Schulz; Damien M. Wu; Shuta Ishigami; Edward Buratto; Duncan MacGregor; Matthew S. Yong; Yaroslav Ivanov; Roberto Chiletti; Christian P. Brizard; Igor E. Konstantinov

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)