Opening book details…
Can I read Atheroma development in apolipoprotein E‐null mice is not regulated by phosphorylation of p27^Kip1^ on threonine 187 on EtoBox?
Atheroma development in apolipoprotein E‐null mice is not regulated by phosphorylation of p27^Kip1^ on threonine 187 by Silvia M. Sanz‐González; Raquel Melero‐Fernández de Mera; Nisar P. Malek; Vicente Andrés is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Atheroma development in apolipoprotein E‐null mice is not regulated by phosphorylation of p27^Kip1^ on threonine 187 about?
## Abstract Excessive cellular proliferation is thought to contribute to neointimal lesion development during atherosclerosis and restenosis after angioplasty. Inhibition of cyclin‐dependent kinase (CDK) activity by p27 inhibits mammalian cell growth. Mounting evidence indicates that p27 negatively regulates neointimal thickening in animal models of restenosis and atherosclerosis, and its expression in human neointimal lesions is consistent with such a protective role. Cell cycle progression is facilitated by cyclinE/CDK2‐dependent phosphorylation of p27 on threonine 187 (T187) during late G1. The purpose of this study was to assess whether this phosphorylation event plays a role during atherosclerosis. To this end, we generated apolipoprotein E‐null mice with both p27 alleles replaced by a mutated form non‐phosphorylatable at T187 (apoE−/−p27T187A mice) and investigated the kinetics of atheroma development in these animals compared to apoE−/− controls with an intact __p27__ gene. Fat feeding resulted in comparable level of hypercholesterolemia in both groups of mice. Surprisingly, aortic p27 expression was not increased in fat‐fed apoE−/−p27T187A mice compared with apoE−/− control
Who reads Atheroma development in apolipoprotein E‐null mice is not regulated by phosphorylation of p27^Kip1^ on threonine 187?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Silvia M. Sanz‐González; Raquel Melero‐Fernández de Mera; Nisar P. Malek; Vicente Andrés
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)