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Mapping Quantitative Trait Loci for Stress Induced Alterations in Porcine Leukocyte Numbers and Functions by I Edfors-Lilja; E Wattrang; L Andersson; C Fossum is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Summary To identify quantitative trait loci (QTLs) with effects on ‘stress’ induced alterations of porcine immune functions, a number of immune capacity traits were analysed in the __F__~2~ generation of a Wild Boar ‐ Yorkshire intercross. All traits were measured prior, and one day after, exposure to experimental ‘stress’ (mixing and transport). The ‘stress’ protocol induced a decrease in numbers of circulating neutrophils and in spontaneous proliferation __in vitro__, whereas phagocytic capacity, mitogen induced proliferation and spontaneous IL‐2 activity increased. The IFN‐α production tended to decrease, although the individual variation was pronounced. More than 200 genetic markers have been scored in the entire pedigree and were used to trace the inheritance of individual chromosome segments. Wild Boar alleles were on average associated with higher mitogen induced IL‐2 activity and a slightly lower decrease in IFN‐α production after mixing and transport. Four QTLs with significant effects were identified; one influencing ‘stress’ induced alteration in numbers of neutrophils (chromosome 8), one influencing spontaneous proliferation after ‘stress’ (chromosome 2), one influen

Who reads Mapping Quantitative Trait Loci for Stress Induced Alterations in Porcine Leukocyte Numbers and Functions?

Author

I Edfors-Lilja; E Wattrang; L Andersson; C Fossum

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0268-9146)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)