Can I read High TOX expression on CD8+ T cells in pure red cell aplasia on EtoBox?

High TOX expression on CD8+ T cells in pure red cell aplasia by Haiyue Niu; Li Yan; Liping Yang; Mengying Zhang; Mengyuan Liu; Jie Ren; Zonghong Shao; Rong Fu; Limin Xing; Huaquan Wang is a Medicine article available to read on EtoBox.

What is High TOX expression on CD8+ T cells in pure red cell aplasia about?

Thymocyte selection-associated high-mobility group box protein (TOX) is an important molecule regulating the development and exhaustion of T lymphocytes. Our aim is to investigate the role of TOX in the immune pathogenesis of pure red cell aplasia (PRCA). TOX expression of CD8 + lymphocytes from the peripheral blood of patients with PRCA was detected by flow cytometry. Additionally, the expression of immune checkpoint molecules PD1 and LAG3 and cytotoxic molecules perforin and granzyme B of CD8 + lymphocytes was measured. The quantity of CD4 + CD25 + CD127 low T cells was analyzed. TOX expression on CD8 + T lymphocytes in PRCA patients was significantly increased (40.73 ± 16.03 vs. 28.38 ± 12.20). The expression levels of PD1 and LAG3 on CD8 + T lymphocytes in PCRA patients were significantly higher than those in the control group (34.18 ± 13.26 vs. 21.76 ± 9.22 and 14.17 ± 13.74 vs. 7.24 ± 5.44, respectively). The levels of perforin and granzyme in CD8 + T lymphocytes of PRCA patients were 48.60 ± 19.02 and 46.66 ± 25.49, respectively, which were significantly higher than those of the control group (31.46 ± 7.82 and 16.17 ± 4.84, respectively). The number of CD4 + CD25 + CD127 low

Who reads High TOX expression on CD8+ T cells in pure red cell aplasia?

Author

Haiyue Niu; Li Yan; Liping Yang; Mengying Zhang; Mengyuan Liu; Jie Ren; Zonghong Shao; Rong Fu; Limin Xing; Huaquan Wang

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)