Can I read The asymmetric synthesis of β-lactams. Stereocontrolled asymmetric tandem Michael additions and alkylations of α,β-unsaturated acyl ligands bound to the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] on EtoBox?

The asymmetric synthesis of β-lactams. Stereocontrolled asymmetric tandem Michael additions and alkylations of α,β-unsaturated acyl ligands bound to the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] by Stephen G. Davies; Isabelle M. Dordor-Hedgecock; Kevin H. Sutton; Jonathan C. Walker is a Chemistry article available to read on EtoBox.

What is The asymmetric synthesis of β-lactams. Stereocontrolled asymmetric tandem Michael additions and alkylations of α,β-unsaturated acyl ligands bound to the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] about?

Michael addition of lithium benzylamide to the enantiomerically pure (S)-E-crotonyl complex of C(~5-C,H,)Fe(CO)(PPh~)l followed by trapping of the resultant enolate with methyl iodide or methanol occurs with high diastereoselectivity and gives after decomplexation the essentially optically pure (3R),( 4S)-(-)-3,4-dimethyl-and (OS)-(-)-4-methyl-N-benzyl-B-lactams respectively. Similarly, tandem addition of lithium benzylamide and methylation of the corresponding enantiomerically pure R-(-)-acryloyl complex gave after decomplexation the essentially optically pure (3S)-(-)-3-methyl-N-benzyl-B-lactam. We have recently reported that the chiral auxiliary [(n"-C,H,)Fe(CO)(PPh,)1 exerts

Who reads The asymmetric synthesis of β-lactams. Stereocontrolled asymmetric tandem Michael additions and alkylations of α,β-unsaturated acyl ligands bound to the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)]?

Author

Stephen G. Davies; Isabelle M. Dordor-Hedgecock; Kevin H. Sutton; Jonathan C. Walker

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

1986

Language

EN

Field

Chemistry (Physical Sciences)