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Comparison of Humoral Response in Kidney Transplant Recipients and Donors and Healthy Volunteers Following Second Dose of SARS-CoV-2 mRNA Vaccine by Hajime Sasaki; Kaori Hasegawa; Hiroshi Harada; Daiji Takamoto; Yusuke Takada; Tetsuo Hirano; Tatsu Tanabe; Hiroshi Tanaka; Masayoshi Miura is a Medicine article available to read on EtoBox.

What is Comparison of Humoral Response in Kidney Transplant Recipients and Donors and Healthy Volunteers Following Second Dose of SARS-CoV-2 mRNA Vaccine about?

Purpose To investigate the kinetics and durability of anti-spike glycoprotein (S) immunoglobulin G (IgG) after the second dose of mRNA-based SARS-CoV-2 vaccine in kidney transplant recipients (recipients) compared with those in kidney donors (donors) and healthy volunteers (HVs) and identify factors negatively associated with SARS-CoV-2 vaccine effectiveness in recipients. Methods We enrolled 378 recipients with no history of COVID-19 and no anti-S-IgG before the first vaccine and who received a second mRNA-based vaccine dose. Antibodies were detected using an immunoassay more than 4 weeks after the second vaccine dose. Anti-S-IgG 60 years and lymphocytopenia (odds ratio: 2.35 and 2.44, respectively). Conclusions Kidney transplant recipients demonstrate delayed and attenuated responses, with lower SARS-CoV-2 antibody titers after the second dose of the mRNA-based COVID-19 vaccine.

Who reads Comparison of Humoral Response in Kidney Transplant Recipients and Donors and Healthy Volunteers Following Second Dose of SARS-CoV-2 mRNA Vaccine?

Author

Hajime Sasaki; Kaori Hasegawa; Hiroshi Harada; Daiji Takamoto; Yusuke Takada; Tetsuo Hirano; Tatsu Tanabe; Hiroshi Tanaka; Masayoshi Miura

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)