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The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis by Eusebio Chiefari; Francesco Paonessa; Stefania Iiritano; Ilaria Le Pera; Dario Palmieri; Giuseppe Brunetti; Angelo Lupo; Vittorio Colantuoni; Daniela Foti; Elio Gulletta; Giovambattista De Sarro; Alfredo Fusco; Antonio Brunetti is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis about?
## Abstract ## Background We previously showed that mice lacking the high mobility group A1 gene (__Hmga1__-knockout mice) developed a type 2-like diabetic phenotype, in which cell-surface insulin receptors were dramatically reduced (below 10% of those in the controls) in the major targets of insulin action, and glucose intolerance was associated with increased peripheral insulin sensitivity. This particular phenotype supports the existence of compensatory mechanisms of insulin resistance that promote glucose uptake and disposal in peripheral tissues by either insulin-dependent or insulin-independent mechanisms. We explored the role of these mechanisms in the regulation of glucose homeostasis by studying the __Hmga1__-knockout mouse model. Also, the hypothesis that increased insulin sensitivity in __Hmga1__-deficient mice could be related to the deficit of an insulin resistance factor is discussed. ## Results We first show that HMGA1 is needed for basal and cAMP-induced retinol-binding protein 4 (__RBP4__) gene and protein expression in living cells of both human and mouse origin. Then, by employing the __Hmga1__-knockout mouse model, we provide evidence for the identification of a
Who reads The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Eusebio Chiefari; Francesco Paonessa; Stefania Iiritano; Ilaria Le Pera; Dario Palmieri; Giuseppe Brunetti; Angelo Lupo; Vittorio Colantuoni; Daniela Foti; Elio Gulletta; Giovambattista De Sarro; Alfredo Fusco; Antonio Brunetti
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 1741-7007)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)